What is Disodium 5′-ribonucleotides (E635)? Uses, Safe, Side Effects

What is Disodium 5′-ribonucleotides (E635)? Uses, Safe, Side Effects


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Disodium 5′-ribonucleotides(E635), also known as disodium Guanosine monophosphate, disodium Guanosine diphosphate, and disodium inosine monophosphate, is an ingredient widely used in processed food. It can be found in soups, breads, and cheese among other things. This is a chemical that has been studied for it nutritional value and is considered safe and healthy to eat.

This article explores the chemical properties, health benefits, and side effects of Disodium 5′-ribonucleotides (E635), its uses, toxicity and research studies done on it.

What is disodium 5′-ribonucleotides?

Disodium 5′-ribonucleotides definition

Disodium 5′-ribonucleotides is a form of nucleotide, which are molecules that make up DNA. It has two parts:

Disodium – This part of disodium 5′-ribonucleotides is an ion (a positively charged particle) with two sodium atoms attached to it. This ion can be found naturally in many foods, including meat and fish.

5′-Ribonucleotides – The other part of disodium 5′-ribonucleotides is ribose, which looks like two hexagons connected by a single bond at their center. Ribose is also found naturally in many foods, including honey and beer.

Where does disodium 5′-ribonucleotides come from?

Disodium 5′-ribonucleotides is a food additive that is used as a flavor enhancer. It is a disodium salt of ribonucleotides, which are compounds found in cells that play an important role in RNA synthesis, DNA replication and repair, protein biosynthesis, and regulation of gene expression.

The source of disodium 5′-ribonucleotides is beef liver, which also provides it with its reddish color.

There are several functions that disodium 5′-ribonucleotides performs in the body. First, it helps to regulate the absorption of carbohydrates into the bloodstream. Second, it helps to regulate blood sugar levels and insulin secretion from the pancreas by inhibiting alpha-glucosidase enzymes in the small intestine. Third, it plays a role in the production of neurotransmitters like dopamine and norepinephrine.

Disodium 5′-ribonucleotides has been shown to help protect against damage done by free radicals on cell membranes and DNA damage caused by oxidative stressors such as cigarette smoke or pollution. The antioxidant properties of disodium 5′-ribonucleotides make it beneficial for heart health as well as for cognitive function since it protects against damage caused.

How is disodium 5 ribonucleotides made?

The production process for disodium ribonucleotides is completely different from that of sodium ribonucleotides. Instead of using a Patented Chemical Manufacturing Process, the disodium ribonucleotides are produced using a chemical manufacturing process:

  1. The first step in the process is to make the monosodium phosphate by reacting sodium chloride with sulfuric acid. This reaction yields sodium sulfate and hydrogen phosphide gas.
  2. Next, this hydrogen phosphide gas is reacted with potassium hydroxide to yield potassium phosphate and hydrogen gas (H2).
  3. Finally, this hydrogen gas is reacted with carbon dioxide at high temperature and pressure to form carbon monoxide (CO) as well as methane (CH4), ethylene (C2H4), acetylene (C2H2), and other hydrocarbons.

Disodium 5′-ribonucleotides is a white powder that is used as a food additive. It is used to improve the taste of products like tea, dairy products, and drinks. It can also be used as a dietary supplement to help increase energy levels and enhance athletic performance.

Disodium 5′-ribonucleotides is made up of two amino acids: adenosine monophosphate (AMP) and guanosine monophosphate (GMP). These two compounds are combined with sodium ions to form disodium 5′-ribonucleotides.


Other Names

  • I+G
  • Sodium ribonucleotides
  • Disodium inosinate and guanylate

CAS Number


Chemical formula

  • C10H11N4O8P · nH2O
  • C10H12N5Na2O8P · nH2O

Molecular Weight







An odourless, white powder or granular substance.


The air is easy to absorb water, and around 20-30% of it is water.


  1. In Water: This product is water soluble, 25g in 100ml water at 20 degrees.
  2. In Organic Solvents: It is sparingly soluble in ethanol, but practically insoluble in ether.

What is disodium 5 ribonucleotides used for?

Disodium 5′-ribonucleotides are a class of nucleotide salts that have been used in some cosmetic products. These compounds have been shown to improve the appearance of skin by increasing epidermal thickness, improving skin barrier function, and preventing moisture loss. They also protect against UV radiation-induced damage and may help prevent aging in skin.

The most commonly used disodium 5′-ribonucleotides include disodium 5′-ribonucleotide tetraethylene glycol (TEGDMA) and disodium 5′-ribonucleotide tetrapropylene glycol (TRP). TEGDMA is often found in hair conditioners while TRP is used as an additive to personal care products such as toothpastes and mouthwashes.

In addition to the levels recommended by the manufacturer, Ajinomoto, here are the common uses of I+G in food:

  • Meat products: ≥ 0.01%
  • Broths: 0.50 – 1.00%
  • Soups: 0.20 – 0.30%
  • Spices (10% salt or higher): 0.25-2.8%
  • Snacks:0.02 – 0.03%
  • Tomato sauce: 0.02 – 0.04%
  • Mustard: 0.02 – 0.04%
  • Salad dressings: 0.01 – 0.02%
  • Vegetable preserves, fish byproducts, frozen food, biscuits and pasta / dough: 0.01%

Is disodium 5 ribonucleotides safe?

There is no doubt that its safety as a food additive has been approved by the United States Food and Drug Administration (FDA), the European Food Safety Authority (EFSA), the  Joint FAO/WHO Expert Committee on Food Additives (JECFA), as well as other authorities.


The FDA has approved disodium guanylate and disodium inosinate as direct food additives that may be used safely as flavor enhancers. However, I cannot find such information about I+G.


As an authorised food additive, Disodium 5′-ribonucleotides (E635) is listed in the European Commission Regulation (EU) No 231/2012, in the category “additives other than colours and sweeteners.”

Its usage level in food and beverages for human consumption needs to be reevaluated in conjunction with IMP and GMP, which was requested in October 2018.

UK Food Standards Agency

The items are categorized as “Others”

Food Standards Australia New Zealand

In Australia and New Zealand, it has the code number 635 and is approved as a food ingredient.


Functional class: Food additives: flavor enhancer.

Acceptable daily intake: In 1974, ADI “not specific” was set.

What are the benefits of disodium 5 ribonucleotides?

In the last few years, there has been a lot of interest in disodium 5 ribonucleotides as a dietary supplement. In fact, it is one of the most popular supplements on the market today.

Disodium 5 ribonucleotides is a combination of two amino acids, thymine and cytosine, which are found in all living organisms. It is also known as dRibose or D-Ribose. This particular form of ribose has been proven to have many health benefits for people who take it regularly.

The benefits of disodium 5 ribonucleotides include:

Heart Health – Many experts believe that this supplement can help to prevent heart disease by improving blood flow to the heart muscle. The improved blood flow will allow more oxygen and nutrients to reach your heart so that it can work more efficiently and effectively. When your heart works better, you will be less likely to suffer from chest pain or other symptoms that come with poor heart health such as high blood pressure and cholesterol levels.

Improved Athletic Performance – If you are an athlete looking for an edge in your sport then disodium 5 ribonucleotides may be just what you need! Studies have shown that taking this supplement regularly will increase strength endurance.

What are the possible side effects of disodium 5 ribonucleotides?

There are no known side effects or interactions with disodium 5 ribonucleotides in humans.

Possible side effects of disodium 5 ribonucleotides

Disodium 5 ribonucleotides is generally well tolerated by most people, but some people may experience side effects when taking it.

The most common side effects of disodium 5 ribonucleotides include:

  • headache (migraine)
  • nausea and vomiting (vomiting)
  • dizziness (lightheadedness)
  • rash (hives)
  • diarrhea
  • fatigue
  • stomach pain

Where to buy disodium 5 ribonucleotides?

Disodium 5′-ribonucleotides are available from many different online retailers(Amazon.com, eBay). Some companies specialize in selling these compounds while others offer them alongside other products like creatine or caffeine supplements. If you’re looking for a specific brand or type of product, it’s best to shop around before making your purchase so you can find one that meets your needs exactly.

In addition to buying disodium 5′-ribonucleotides from an online retailer, some manufacturers also sell their products directly from their own websites. This allows consumers to learn more about these compounds before making a purchase.

Frequently asked questions

Is disodium 5 ribonucleotides natural?

Yes, it is natural. Disodium 5 ribonucleotides is a naturally occurring substance found in honey and other plant and animal tissue. It is also used as an additive to food products such as cheeses, meats and beverages.

Is disodium 5 ribonucleotides halal?

Disodium 5 ribonucleotides is halal. disodium 5 ribonucleotides is an ingredient derived from polyribonucleotides, which are found in the nuclei of cells. Polyribonucleotides are also known as nucleic acids and are made up of a mixture of three types of bases: adenine, thymine, and cytosine. The disodium 5 ribonucleotides found in food products are created by treating polyribonucleotides with sodium hydroxide and hydrogen chloride to remove one of the phosphate groups that link together the sugar-phosphate backbones within the molecule. After this process is complete, the resulting disodium 5 ribonucleotide can be used in food products without any further processing required.

Because disodium 5 ribonucleotide is derived from polyribonucleotides, it qualifies as halal according to Islamic law.

Is disodium 5 ribonucleotides vegan?

Yes, disodium 5 ribonucleotides is vegan-friendly. This product is made from a non-animal source, so it does not contain any animal products.

Is disodium 5 ribonucleotides kosher?

Yes, disodium 5 ribonucleotides are kosher.

Disodium 5 ribonucleotides, also known as disodium inosinate and disodium guanylate, are monosodium salts of inosine and guanosine. They are used as flavor enhancers in foods and beverages. The kosher diet prohibits the consumption of pork. Therefore, if a food contains pork, it cannot be kosher. Disodium 5 ribonucleotides do not contain any pork products, so they are kosher-approved.

Is disodium 5 ribonucleotides gluten free?

Yes, disodium 5 ribonucleotides is gluten free. Disodium 5 ribonucleotides is part of a group of compounds called nucleotides. Nucleotides are typically used as additives in food products, and are often added for their ability to bind with water and improve the texture of baked goods, among other things.

Disodium 5 ribonucleotides is also known as disodium guanosine monophosphate or disodium inosine monophosphate, and it is a molecule that contains five phosphate groups attached to one ribose ring (the building block of RNA).


Disodium 5 ribonucleotides, is a synthetic chemical compound produced from guanosine and cysteine under alkaline conditions. It is a nucleotide in chemical terminology and widely present in the foods that are rich in protein. The “sodium” used most often in its abbreviation E 635 comes from sodium salt of the compound. It has common food additive number E635 and approved by FDA as a food additive. Disodium 5′-ribonucleotides are also referred to by other names such as RIBONUCLEOTIDE SODIUM DIPHOSPHATE, disodium 5′-ribonucleotides dihydrate, disodium 5′-ribonucleotides monosodium phosphate salt, disodium 5′-ribonucleotides trihydrate, di- sodium 5 ‘ ribonucleotides dihydrate, disodium 5 ‘ penta- acetate tetrahydronucleotide ester and disodium 5 -ribonucleotide ester sodium salt hydrate.

Sophie Feng

Sophie Feng

Sophie Feng is the author of gradechemical.com, she is the co-founder of the grade chemical network. She has been in grade chemical company since 2017, with a working knowledge of food chemical .

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