What is Sodium Gluconate (E576) in food? Uses, Safe, Side Effects

What is Sodium Gluconate (E576) in food? Uses, Safe, Side Effects


Table of Contents

Sodium gluconate (E576) – is a food additive and health supplement. It is often found in low-sodium and salt-free foods. Some kinds of crustacean like prawn, crab, etc. contain lots of sodium gluconate naturally. Let’s take a look at the definition, uses, side effects and more of sodium gluconate.

What is sodium gluconate?

Sodium gluconate is a salt of gluconic acid. It is used as a chelating agent and preservative in foods, pharmaceuticals and cosmetic products. As an antioxidant it can be used as an alternative to BHT (butylated hydroxytoluene).

Sodium gluconate is soluble in water and ethanol, but not in methanol or acetone. It is usually considered stable with respect to hydrolysis under most conditions at room temperature.

Mono sodium gluconate

Mono sodium gluconate is a sweetener that is used in a wide variety of foods and beverages. It is often used as a substitute for sugar, because it is sweeter than sugar but has less calories and none of the negative effects associated with sugar.

Mono sodium gluconate is also called E-957, E-958 or E-959 depending on its application.

Mono sodium gluconate is made by reacting gluconic acid with sodium carbonate. The resulting product contains at least 60% monosodium salt of gluconic acid. As a food additive, this product has an E number designation (E-957), which means that it can be added to foods without prior approval from national regulatory bodies such as the Food and Drug Administration (FDA) in the United States or the European Union’s Scientific Committee for Food (SCF).

Ferric sodium gluconate

Ferric sodium gluconate is an iron salt of gluconic acid. It is a dark brown powder with a bitter taste. The chemical formula for ferric sodium gluconate is FeNa(C6H11O7)3.

Ferric sodium gluconate, which is also known as ferric gluconate, is used in foods and beverages as a color stabilizer and antioxidant. The compound has been found to have antimicrobial properties and may be used as an additive in cosmetics, soaps, toothpastes and mouthwashes as well as pharmaceuticals.

Sodium gluconate chelating agent

Sodium gluconate chelating agent is a chemical compound that can bind to other metal ions, making them soluble in water. It is one of the most commonly used chelating agents in the world today. This compound is available in different forms, such as powder, liquid and tablet. It is also used as a food additive or preservative to prevent food from spoiling.

Sodium gluconate chelating agent has many industrial applications. For example, it can be used in water treatment to remove heavy metals from water. It can also be used as an additive for concrete and ceramic tiles to increase their strength and resistance to corrosion by alkaline solutions.

Antimony sodium gluconate

Antimony Sodium Glucarate is a prescription drug that belongs to the class of medications called antidiabetic agents. It works by helping the body use insulin more effectively and helps in the production of insulin by the pancreas. It is used along with diet and exercise to control high blood sugar in people with type 2 diabetes mellitus.

Sodium gluconate SDS

Sodium gluconate sds is a white crystalline powder. It is soluble in water and insoluble in alcohol.

How is sodium gluconate made?

Sodium gluconate is an inorganic salt made by the neutralization of gluconic acid with sodium hydroxide.

Gluconic acid is produced industrially by the fermentation of glucose by certain species of bacteria. The resulting gluconic acid is purified and converted to sodium gluconate by a process which involves heating it with sodium hydroxide and then cooling it to precipitate the salt.

What is sodium gluconate made of?

Sodium gluconate is a salt of gluconic acid. It is produced by the oxidation of glucose, using dilute sulfuric acid as an oxidizing agent. Sodium gluconate can be used as an antiseptic, and has been shown to have anti-inflammatory properties.

Sodium gluconate is used in the treatment of hypoglycemia (low blood sugar levels) in dogs, cats and horses. It is also effective for treating urolithiasis (formation of bladder stones), which occurs when urine becomes concentrated due to dehydration.

Gluconic acid vs sodium gluconate

Gluconic acid and sodium gluconate are two different chemicals that have the same molecular formula, C6H11O7. The two compounds differ in their physical properties and applications.

The difference between Gluconic acid and sodium gluconate lies in the number of hydrogen atoms present in them. Gluconic acid has one more atom of oxygen than sodium gluconate; this is why it has a higher pKa value (4.55) than sodium gluconate (4.10). This means that the carboxyl group in gluconic acid is more acidic than that of sodium gluconate, which makes it more active as an acid catalyst than sodium gluconate.

Both these compounds are soluble in water, but they have different solubilities at different temperatures. Gluconic acid has a lower solubility than sodium gluconate at room temperature but higher at high temperatures (between 100°C and 150°C). On the other hand, sodium gluconate has a higher solubility at room temperature but lower at high temperatures (above 100°C).

What is sodium gluconate used for?

Sodium gluconate is a salt that occurs naturally in the body, and is often used as a food additive. It’s commonly used as an anticoagulant in blood transfusions, but it also has other applications.

Sodium gluconate in food

Sodium gluconate is used as a preservative in cheese, butter and other dairy products. It is also used as a food additive to help retain moisture in breads and cakes. To prevent premature spoilage, sodium gluconate can be added to fruit drinks and fruit juices. It is also found in canned fish products or meat products that have been brined or pickled.

Sodium gluconate in pharma & nutraceutical

Sodium gluconate is a salt of gluconic acid, a naturally occurring organic acid often used in foods and pharmaceuticals. It is used as a preservative in the pharmaceutical industry and as an anti-oxidant in the food industry.

It can be found in the following products:

  • Syrups
  • Suspension
  • Swallowable/orally dispersible tablets
  • Hard capsules
  • Others

Sodium gluconate uses in cosmetics

Sodium gluconate is used as an anti-irritant agent in cosmetics and beauty products such as deodorants, antiperspirants and skin creams. It helps to reduce redness and itching of sensitive skin caused by shaving or waxing procedures by reducing the amount of free radicals in the skin which cause these reactions. In addition, it prevents the formation of free radicals that are responsible for aging of the skin due to oxidation reactions that occur over time when exposed to sunlight or environmental pollutants such as cigarette smoke or smoggy air pollution from industrial plants or traffic congestion on busy streets with heavy traffic flow during rush hour traffic jams.

Sodium gluconate for skin

Sodium gluconate skin care

Sodium gluconate has been used topically to treat mild skin diseases such as eczema and psoriasis by promoting keratinization of the stratum corneum (outermost layer of skin). It may also help with acne by reducing inflammation or acting as a mild exfoliant to remove dead surface cells.

Sodium gluconate for hair

Topical treatment of sodium gluconate has been shown to increase hair shaft thickness and improve hair growth in both men and women suffering from alopecia areata (a condition affecting immune system).

Sodium gluconate in soap

Sodium gluconate is used in soaps because of its ability to make lather more easily. It also helps to make soap milder on the skin.

Industrial uses

Chelating agent

Sodium gluconate is used as a chelating agent because it can help remove heavy metals from the body, including mercury and lead. This can help reduce symptoms of poisoning with these metals and prevent further damage to your organs and tissues.

As a result of this property, it is widely used in:

  • Water treatment
  • Bottle washing
  • Corrosion inhibition
  • Metal surface treatment
  • Industrial cleaning

Concrete retarder

The addition of sodium gluconate will increase the setting time of concrete by up to 50 percent while still allowing the concrete to cure properly. This makes it ideal for use in situations where you need a stable surface quickly such as when building roads or bridges over water bodies or on unstable ground such as slopes or hillsides.


Other names
  • Sodium d-gluconate
  • Sodium salt of D-gluconic acid
CAS number 527-07-1
Chemical formula NaC6H11O7
Molecular weight 218.137



Image Source

In the chemical structure, there are five hydroxyl groups and one carboxylic acid group.



Powder or granules that are white to tan in color.


Easily soluble in water, sparingly soluble in ethanol.


In the range of 6.5 and 7.5 (10% solution)

Is sodium gluconate safe to eat?

As a matter of fact, it has been approved as safe by the U.S. It includes the Food and Drug Administration (FDA), the European Food Safety Authority (EFSA), as well as the Joint FAO/WHO Expert Committee on Food Additives.


As a sequestrant in food, sodium gluconate is generally regarded as safe (GRAS).


In Commission Regulation (EU) No 231/2012, sodium gluconate (E576) is listed as an authorised food additive under the category “other than colours and sweeteners”.

Approved uses

A “Group I” item has a maximum use level of “quantum satis”, which means that there is no specific limit to its use. It may be present in the following foods:

  • Dairy products
  • Fats and oils and fat and oil emulsions
  • Fruit and vegetables
  • Confectionery
  • Cereals and cereal products
  • Bakery wares
  • Meat
  • Fish and fisheries products
  • Eggs and egg products
  • Table-top sweeteners
  • Salts, spices, soups, sauces, salads and protein products
  • Beverages

UK Food Standards Agency

The item is categorized under “Others”

Food Standards Australia New Zealand

With the code number 576, it is an approved ingredient in Australia and New Zealand.


Function Class: food additives, sequestrant and yeast food.

Acceptable daily intake: In 1998, ADI “not specified” was paired with glucono delta-lactone and other gluconates.

What are the benefits of sodium gluconate?

Sodium gluconate is a salt of gluconic acid, a mild alpha-hydroxy acid (AHA). Sodium gluconate is used as an antiseptic and for topical treatment of wounds and ulcers. It is also used in the treatment of vaginal yeast infections and other conditions.

Sodium gluconate has been used as a substitute for sodium bicarbonate to treat alkalosis.

It also helps with:

  • wound healing
  • itchy skin conditions like eczema or psoriasis
  • gum disease, mouth sores, canker sores, sore throat, strep throat
  • vaginal yeast infections

What are the side effects of sodium gluconate?

Side effects of sodium gluconate include:

  1. Allergic reactions. Side effects of sodium gluconate may include rash, itching, and other allergic reactions.
  2. Nausea and vomiting. Sodium gluconate can cause nausea and vomiting.
  3. Diarrhea. Sodium gluconate may cause diarrhea in some people; however, this is not common. If you experience diarrhea after taking sodium gluconate, contact your physician.

If you have a high potassium level or kidney disease, you should avoid taking sodium gluconate because it could worsen your condition.

Is sodium gluconate bad for you?

Sodium gluconate is a salt of gluconic acid, a type of acid. Gluconic acid is produced by the fermentation of glucose by yeast, fungi and bacteria. It is also found naturally in honey, wine and fruit juice.

It’s used in many household products like shampoo and toothpaste as well as cosmetics and personal care products.

While there’s no evidence that sodium gluconate causes any health problems in humans, it may irritate some people’s skin or mucous membranes if they come into contact with it.

In addition, because it can be an irritant to the digestive tract if ingested in large quantities, it should only be taken orally under a doctor’s supervision if you have kidney disease or other medical conditions that affect your kidneys’ ability to filter out waste products from your blood.

Where to buy sodium gluconate?

The following are some of the places you can buy sodium gluconate:

  • Amazon.com – This site offers a wide variety of sodium gluconate products with different sizes and prices. You can also buy it on eBay by searching for the product name.
  • CVS – They have a limited number of options compared to Amazon but they’re still good options if you’re looking for this product at an affordable price point (about $1).

Frequently asked questions

Is sodium gluconate natural?

Yes, sodium gluconate is natural.

Sodium gluconate is a naturally occurring mineral that is produced by plants and animals. It’s found in beets and can also be made synthetically.

Is sodium gluconate halal?

The answer to this question depends on the origin of the sodium gluconate. If it is processed from wheat, barley, or rye, then it is not halal. However, if it is made from any other ingredient, such as sugar beets or potatoes, then it would be halal.

Is sodium gluconate vegan?

Yes, sodium gluconate is vegan.

Sodium gluconate is a salt of gluconic acid. Gluconic acid is an organic acid that can be found in plants, fruits and vegetables.

Is sodium gluconate kosher?

Yes, sodium gluconate is kosher.

Sodium gluconate is a salt of gluconic acid, which can be derived from many sources, including cellulose and carbohydrates.

Is sodium gluconate gluten free?

Yes, sodium gluconate is gluten-free. It is derived from glucose, which is a simple sugar that occurs naturally in many fruits and vegetables.

Is sodium gluconate safe for skin?

Sodium gluconate is safe for skin. It is a salt that can react with other chemicals to form a solid, so it should be stored away from acids and bases.

It is often used as an astringent in skincare products, but it can also be used to treat eczema and other skin conditions.

Is sodium gluconate safe?

Sodium gluconate is safe when used as directed by a doctor or pharmacist.

When used in small doses, sodium gluconate can be used to treat hyperkalemia (high potassium levels) and hypocalcemia (low calcium levels), among other conditions.

It’s important to note that if you’re using sodium gluconate for the first time, it’s best to start with a low dose and work your way up. If you have any questions about the safety of taking sodium gluconate, talk to your doctor or pharmacist about it.


Sodium gluconate (E576) is a sodium salt of gluconic acid and has been widely used as a food additive to extend the shelf life of food and to prevent mold. It is usually used in foods that have a long shelf lifetime. It can also be used with calcium gluconate to control tartar formation in pet foods and has been shown in laboratory studies to inhibit human tumor cells from growing. Sodium Gluconate is also a component for EDTA chelation therapy but it is not nearly as strong as the other chelations: deferoxamine, desferrioxamine, or DFO for its ability to remove iron from the body.

Sophie Feng

Sophie Feng

Sophie Feng is the author of gradechemical.com, she is the co-founder of the grade chemical network. She has been in grade chemical company since 2017, with a working knowledge of food chemical .

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