What is Calcium Disodium EDTA E385 in Food: Uses, Safe, Side Effects

What is Calcium Disodium EDTA E385 in Food: Uses, Safe, Side Effects

calcium disodium EDTA

Table of Contents

Calcium disodium EDTA is a chemical compound, (C8H7CaNaO12)2H2D2. It is used as an additive to drinking water and in food products because of its chelating properties. This chemical is better known by its common name, Calcium Disodium EDTA E385 or EDTA. These are not the only names that are used for this chemical.

What is calcium disodium EDTA?

Calcium disodium EDTA is a food additive that helps prevent the formation of kidney stones by binding to minerals in the urine. It’s used in many foods and beverages, including bottled water, soft drinks, beer and wine.

It’s also used to treat lead poisoning in children and as a preservative in medications.

Calcium disodium EDTA is also known as tetrasodium EDTA, disodium EDTA and ethylenediaminetetraacetic acid (EDTA).

Calcium disodium EDTA is a white powder that dissolves easily in water or ethanol but not fats or oils. It is stable at room temperature but decomposes at higher temperatures.

Calcium disodium EDTA was first identified in 1957 as a compound called edetate calcium disodium (EC), which was isolated from the blood of animals fed diets containing calcium carbonate (CaCO3).

Calcium disodium EDTA has been used since 1959 as an additive for canned foods to prevent caking and clumping during storage. It is currently approved for use in more than 80 countries worldwide under various names such as edetate calcium disodium, E 331 and CAS No. 68348-56-8

What is calcium disodium EDTA used for?

Calcium disodium EDTA is a chelating agent, which means it can bind to metal ions. This makes it useful for removing heavy metals from the body. It is also used as an ingredient in some foods, cosmetics, and personal care products.

Calcium disodium EDTA has been used as an ingredient in food since the early 1950s. It’s added to canned foods like soups, sauces, and vegetables to prevent them from discoloring while they are being stored on grocery store shelves. When calcium disodium EDTA is added to these products, it binds with any iron or copper that may exist naturally in the food product. This prevents the formation of dark pigments that can develop when these metals react with air or light exposure during storage.

Calcium disodium EDTA is also used as an additive in other foods such as cheese spread and yogurt drinks because it prevents clumping of ingredients during processing and helps prevent spoilage at high temperatures during shipping or storage.

When calcium disodium EDTA comes into contact with water or saliva, it breaks down into its two main components: sodium and ethylenediaminetetraacetic acid (EDTA). Sodium does not

What is calcium disodium EDTA made of?

Calcium disodium EDTA is the chemical name for ethylenediaminetetraacetic acid (EDTA). The calcium portion of this complexing agent is an ionic charge that binds to heavy metals and minerals. The disodium part of the molecule prevents the formation of crystals in the solution.

Calcium disodium EDTA may be made using several different methods:

– by reacting ethylenediamine with sulfurous acid (H2S04) at high temperatures;

– by reacting ethylenediamine with sulfamic acid (H2NCH2SO3H) at high temperatures;

– by reacting ethylenediamine with methanol and sulfuric acid (H2SO4); or

– by reacting ethylenediamine with nitric acid (HNO3).

What is calcium disodium EDTA in food?

Calcium disodium EDTA is a food preservative. It’s also a chelating agent, which means it binds with metal ions in the body to prevent them from being absorbed by the gastrointestinal tract.

Calcium disodium ethylenediaminetetraacetate (commonly known as calcium disodium EDTA) is used as a food additive, particularly in canned foods and bottled beverages. It may be present in other products as well. Calcium disodium EDTA is also used in drugs and cosmetics to prevent discoloration or other reactions that can occur when the product comes into contact with metal ions.

The purpose of adding this preservative to food is to prevent spoilage due to bacterial growth and oxidation — processes that cause food to develop an unpleasant odor or taste or become discolored. In addition, calcium disodium EDTA prevents yeast molds from growing on fruit juices or grape-based products such as red wine and sherry.

Calcium disodium EDTA can be found in many types of canned goods including soups and vegetables, baby foods, fruits and fruit juices, fish products such as anchovies, sardines, and tuna fish; juices made from concentrate like orange juice; snacks like potato chips

How is calcium disodium EDTA made?

Calcium disodium EDTA is a compound that acts as a sequestrant in the food industry. It binds with metal ions, such as iron and copper, and prevents them from causing oxidation in packaged foods. Calcium disodium EDTA is made commercially by treating ethylene diamine with sodium cyanide to form 1,2-diaminoethane. This is reacted with calcium hydroxide to form calcium hydrogen carbonate, which is then heated to release carbon dioxide. The product can be isolated by acidification of the solution and crystallization.


Other Names
  • Calcium disodium ethylene diamine tetra-acetate
  • Edta calcium disodium
  • Disodium calcium edta
  • Calcium disodium edetate
CAS Number 62-33-9
Chemical formula C10H12O8CaN2Na2·2H2O
Molecular Weight 410.31


The powder or granules have a faint, salty taste and are white and odorless.


Ethanol is practically insoluble in water, but freely soluble in water.



What is the application of calcium disodium EDTA?

Calcium disodium EDTA is a water-soluble chelating agent that is used as an antioxidant and preservative in food, cosmetics, and pharmaceuticals.

Calcium disodium EDTA is an effective metal chelator that forms complexes with divalent (M2+) ions such as calcium and magnesium, which are present in high concentrations in blood plasma. The formation of these complexes is reversible, so the ions can be released by hydrolysis or by reduction.


A common use of calcium disodium EDTA in canned foods is as a chelating agent, preservative, and antioxidant. The metal cations it binds with stabilize food by stabilizing it.

Foods that are canned, sealed, heated, and sterilized are processed to extend their shelf life. There are mainly preservatives, antioxidants, sweeteners, and synthetic colors added to canned foods.

Carbonated beverages

The calcium disodium EDTA in soft drinks promotes flavor retention and reduces discoloration and turbidity.

A preservative, it preserves the freshness and taste of Coca-Cola’s beverages.

Calcium disodium EDTA prevents uncontrolled metal ions from interfering with vitamin C fortified beverages, which deteriorate colors and reduce shelf life. In addition, it can preserve antioxidants in vitamins A, B, D, and E.


According to the European Commission database on cosmetic substances and ingredients, it acts as a chelating agent in cosmetics and personal care products. It is commonly found in lotions, creams, and soaps.


Calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA) is used in the pharmaceutical industry because of its ability to form complexes with transition metals and other ions. This property allows it to act as a chelating agent which can remove trace amounts of heavy metals from the solution.

Is calcium disodium EDTA safe to use?

Calcium disodium EDTA is a food additive that helps prevent the growth of molds and yeasts in food products. It also enhances calcium absorption in the body. The FDA considers calcium disodium EDTA to be generally recognized as safe (GRAS). That means there’s enough evidence to believe it’s safe for human consumption.


In the following food categories, calcium disodium EDTA can be safely used to promote color, flavor, texture retention, and other functions:

  • Cucumbers and cabbage pickled
  • Fermented malt beverages, canned carbonated soft drinks
  • The canned white potato
  • Cooked canned food
  • Dressings, salad dressings, spreads, sauces
  • Pecan pie filling, potato salad, mayonnaise, oleomargarine
  • Dry pinto beans processed
  • A sandwich spread flavored with lemon or orange and artificially colored
  • Eggs that have been hard-cooked


In Regulation (EU) No 231/2012, calcium disodium EDTA (E385) is listed as an authorized food additive, categorized as “additives other than colors and sweeteners.”

Authorised Uses And Use Levels

It may be found in the following foods with maximum levels ranging from 75 mg/kg to 250 mg/kg:

  • Fats that can be spread
  • Mushrooms, artichokes, legumes, and pulses
  • Heat-treated meat products: lamb, lamb eschben, lamb tömbben
  • Crustaceans that have been frozen or deep frozen
  • Fish, crustaceans, and molluscs in canned and bottled form
  • Sauces that are emulsified

UK Food Standards Agency

This item is categorized as “Others”

Food Standards Australia New Zealand

The code number 385 is used in Australia and New Zealand.


Classification: additives, preservatives, sequestrants.

The ADI was set in 1973 at 2.5 mg/kg.

Difference between calcium disodium EDTA and disodium EDTA

The calcium disodium EDTA is a chelating agent, which is used to remove heavy metals from the body. The purpose of using this chemical is to prevent the build-up of heavy metals in the body.

The disodium EDTA is a chelating agent, which is used in water purification systems. The purpose of using this chemical is to remove heavy metals from water.

There are many differences between these chemicals but there are also some similarities between them.

The difference between these two chemicals lies in their molecular structure and how they interact with other compounds. The disodium EDTA can be considered a salt, while the calcium disodium EDTA cannot be considered a salt because it does not have an acidic hydrogen atom.

Both calcium disodium EDTA and disodium EDTA are used as an additive in many food products, medicines, and cosmetics. Calcium disodium EDTA has been approved by the FDA whereas there are no reports about its approval by any other government agency.

Both calcium disodium EDTA and disodium EDTA contain sodium ions and calcium ions but have different charges. Calcium disodium EDTA contains two positive charges while disodium EDTA contains two negative charges per molecule of its structure.

What is the calcium disodium EDTA side effects?

The calcium disodium EDTA side effects can include nausea, vomiting and diarrhea. Ingestion of large amounts of EDTA can lead to a syndrome called acute toxicity. It may also cause elevation in blood pressure, hypotension (low blood pressure) and electrocardiographic changes such as flattening of T waves and prolongation of the QT interval. It may also cause anemia due to decreased absorption of iron and vitamin B12.

The calcium disodium EDTA side effects include:

  • Nausea and vomiting
  • Diarrhea
  • Acute toxicity (symptoms include nausea, vomiting, headache, dizziness, tachycardia, hypotension, cyanosis, and weakness)
  • Elevated blood pressure (hypertension)
  • Hypotension (low blood pressure)
  • Electrocardiographic changes such as flattening of T waves and prolongation of QT interval

Yes. It’s a preservative with a high concentration of aluminum and is banned in many countries.

It’s not good for you because it has a high concentration of aluminum, which is a neurotoxin that causes Alzheimer’s disease and other neurological disorders. The FDA has listed it as unsafe, but it’s still used in many products because it increases shelf life.

If you’re concerned about your exposure to this chemical, avoid products that contain EDTA, especially those with anti-caking agents or anti-foaming agents (they may also contain EDTA).

Where to buy calcium disodium EDTA?

Calcium disodium EDTA is available in powder form, as well as a liquid solution. The powder is used to make your own topical solution, while the liquid can be applied directly to the skin.

You can find calcium disodium EDTA in your local health food store, but if you’re looking for a specific brand name or product, then you’ll want to buy online. Some sites offer free shipping or have other deals that can save you money on your purchase.

You’ll find many different brands and products for sale online. Some of these are sold at discounted prices and come with free shipping if you order over a certain amount. You may also be able to find coupons or discounts that will help save you money on your purchase.

if you purchase in a large quantity, you can consider purchasing from Grade Chemical. which is one reliable calcium disodium EDTA manufacturer in China. they can deliver to you by courier and the price is much more competitive than the local market.

Frequently asked questions

Is calcium disodium EDTA natural?

No,  Calcium disodium EDTA is not a natural compound. It is a synthetic chemical that was created in the laboratory and put into use in the 1950s.

Is calcium disodium EDTA vegan?

Yes, calcium disodium EDTA is vegan. Calcium disodium EDTA is a chemical that’s used in the food industry to prevent calcium from forming lumps in products like cheese and chocolate. It’s also used as a preservative in some personal care products, including toothpaste, shampoos, and conditioners. The chemical does not contain any animal ingredients or byproducts.

Is calcium disodium EDTA dairy free?

Calcium disodium EDTA is not dairy-free. It’s made with a form of calcium and sodium, both of which are derived from milk products.

Is calcium disodium EDTA halal?

Yes, According to Islamic Law, it is permissible and meets the conditions of Halal, so it is generally recognized as halal. We can also find some manufacturers who are MUI Halal-certified.

Is calcium disodium EDTA kosher?

Calcium disodium EDTA is not kosher. EDTA stands for ethylene diamine tetraacetic acid and is a preservative that keeps food fresh by binding metal ions in the food, which helps prevent oxidation. Calcium disodium EDTA is used as a chelating agent in cosmetics, pharmaceuticals, and food products. The two types of EDTA are calcium disodium EDTA and disodium EDTA; both are kosher.

Is calcium disodium EDTA gluten free?

Calcium disodium EDTA is not gluten free. In fact, it’s one of the most widely-used ingredients in many gluten-containing products. This is because it’s often used as a preservative to prevent mold and other contaminants from forming in food products.


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Sophie Feng

Sophie Feng

Sophie Feng is the author of gradechemical.com, she is the co-founder of the grade chemical network. She has been in grade chemical company since 2017, with a working knowledge of food chemical .

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