What is Sodium Dehydroacetate E266? Uses, Safe, Side Effects

What is Sodium Dehydroacetate E266? Uses, Safe, Side Effects

sodium dehydroacetate in food

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Sodium dehyroacetate, also known as Sodium Hydrogen Dehydroacetate, is a white crystalline powder or granules. It usually comes in the form of granules. This compound has many uses and its applications are varied as compared to other additives. It does not affect the flavor or smell of food or beverages and is widely used by various food producers.

It can be used to inhibit bacterial growth on any surface of a product and prevents the appearance of yeasts and molds. This article focuses on different aspects related to Sodium Dehydroacetate such as its uses, safety, side effects and many more.

What is sodium dehydroacetate?

Sodium dehydroacetate is a preservative used in some food and cosmetics products. It can be found in a variety of products, including baked goods and cosmetics.

Sodium dehydroacetate is part of the sodium salt family of preservatives. It is also known as E266 or Natrosol 250 HHR. The chemical formula for sodium dehydroacetate is CHNaO2NaCH2COONa, where “n” represents the number of sodium ions present in the molecule.

Sodium dehydroacetate was first approved by the U.S. Food and Drug Administration (FDA) in 1949 under regulations governing food additives. It has since been approved for use in many other countries around the world, including Canada, Australia and Japan.

What is sodium dehydroacetate used for?

Sodium dehydroacetate is a food additive that is used in the production of cheese, butter, and dried potatoes. It helps to prevent the growth of mold and extend the shelf life of these products.

Sodium dehydroacetate has also been used in cosmetics for its ability to inhibit the growth of microorganisms.

Sodium Dehydroacetate Uses:

In Food: Sodium dehydroacetate is used as a preservative in foods such as cheese, butter, and dried potatoes. The compound works by preventing the growth of mold on these foods, which helps to extend their shelf life.

In Cosmetics: Sodium dehydroacetate is used in cosmetics as an anti-bacterial agent. It works by inhibiting the growth of microorganisms such as bacteria, yeast, and fungi.

What is sodium dehydroacetate made from?

Sodium Dehydroacetate is made from acetic acid, which is derived from corn. It is used as a preservative in cosmetics and beauty products to prevent the growth of bacteria, mold, and yeast.

Sodium Dehydroacetate is a food additive that is used as a preservative in many products. It is also known as sodium salt of dehydroacetic acid and has the chemical formula CHNaOCHCOOCH. Sodium Dehydroacetate is often used in combination with other preservatives, such as potassium sorbate, calcium propionate and benzoates.

Sodium Dehydroacetate was first approved for use by the U.S. Food and Drug Administration (FDA) in 1991. It is approved in many countries around the world, including Australia, Canada and New Zealand.

What’s the application of sodium dehydroacetate?

The solution of sodium dehydroacetate can be used directly on the food for mixing or it can be premixed with other ingredients first, and it can also be used for soaking, spraying, and surface treatment.

The two most common food uses are bread and pastries.


SDHA inhibits the activity of baker’s yeast, resulting in a longer fermentation time for bread (which uses yeast to increase volume). Additionally, baking at temperatures above 130°C will lead to the loss of SDHA.

SDHA microencapsulated in cellulose can reduce the loss of this ingredient caused by high temperature by weakening SDHA’s effect on baker’s yeast fermentation.


As potassium sorbate and sodium dehydroacetate are commonly used to preserve pastries, the combination has less preservation effect because most pastries have an alkaline PH.

As an acidity regulator, glucose delta-lactone can be added to improve the preservation of the two ingredients in pastries.


Preservatives such as this can be used in cosmetics and personal care products to prevent microorganism growth and reproduction.

You may find it in the following products:

  • Lotion
  • Bath
  • Skin care
  • Makeup


Moreover, it can be used to preserve feed for livestock and poultry, such as pig and broiler feed.

How is sodium dehydroacetate made?

Following is a brief description of the manufacturing process for its food grade:

  1. Polymerize diketene to obtain dehydroacetic acid (acesulfame potassium is also produced with this material).
  2. Reaction with sodium hydroxide for neutralization

Here is a general flow chart:



The chemical formula of this powder is C8H7NaO4*H2O, with a molecular weight of 208.15.




  • It is easily soluble in water (1g/3mL), propylene glycol (1g/2mL) and glycerin (1/7mL).
  • It is slightly soluble in ethanol (1%) and acetone (0.2%).


Sodium dehydroacetate is effective against yeast, mold, and bacteria on a broad spectrum. Between 0.05% and 0.10% is the effective concentration.

The inhibitory effect of sodium dehydroacetate is similar to that of sodium benzoate, the traditional preservative:

  • It is about 40-50 times stronger on molds
  • The inhibitory effect is 15-20 times stronger on bacteria.


The antibacterial properties of preservers are dependent on their PH value. These are the optimal pH ranges for common preservatives:

It is clear that these preservatives are only effective in an acidic environment. Since sodium dehydroacetate is effective in acidic as well as alkaline conditions, its antibacterial effect is not much affected by acidity and alkalinity.


Sodium dehydroacetate and dehydroacetic acid are approved as preservatives by the U.S. Food and Drug Administration (FDA).

Is sodium dehydroacetate safe to eat?

Sodium dehydroacetate is used as a preservative in some foods, including potato chips and other snacks. It has also been used as an additive in cosmetics, but it’s not approved for use in food products.

Sodium dehydroacetate is a chemical preservative that’s found naturally in apple peels and beetroots. It’s a mixture of sodium ions, water, and acetic acid (vinegar).

The European Food Safety Authority (EFSA) has approved sodium dehydroacetate for use in foods. The EFSA considers it safe for use at levels up to 0.6% in ready-to-eat foods, such as dried fruit and salted fish products like pickled herring. However, the agency recommends limiting its use to one year because there isn’t enough information about how long it might remain stable or how much exposure people could have while eating the foods over time.

In the U.S., the Food and Drug Administration (FDA) hasn’t approved sodium dehydroacetate as an additive for food products, but it hasn’t banned it either. This means that manufacturers can legally add small amounts of this preservative to their products without getting approval from the FDA first (although they must follow certain labeling requirements).

What are the side effects of sodium dehydroacetate?

Sodium dehydroacetate is a form of sodium, which is a mineral needed by the body in small amounts. Both sodium and sodium dehydroacetate are used as preservatives in some foods and as antiseptics in medical settings. Dehydroacetic acid is also used as an industrial solvent and insecticide.

The most common side effect of sodium dehydroacetate is nausea, which may occur shortly after taking it. In some cases, this may be delayed for several hours after taking the drug. Vomiting may also occur with dehydration from diarrhea or intestinal obstruction from blockage of the intestines by a tumor or other condition.

Numbness of hands or feet can also be a side effect of sodium dehydroacetate if it gets into your bloodstream through a needle puncture during injection or IV administration. Other serious side effects include breathing problems such as shortness of breath or difficulty breathing (respiratory distress) and changes in mental status such as confusion (dementia), disorientation, coma or delirium (confusion).

Where to buy sodium dehydroacetate?

Sodium dehydroacetate is a food additive that is used as a preservative, antioxidant and flavoring agent. It is also used in the treatment of epilepsy and it has many other uses. You can find it in the local drug stores or online. Here are some places where you can buy sodium dehydroacetate:

Amazon.com –  Sodium Dehydroacetate is available on amazon.com for $1.95 for 1 lb, which is about 10% of the price that it is sold at Walmart and other online stores.

Walmart – Sodium Dehydroacetate can also be purchased from walmart stores. The price is $6 per pound, which is about 3 times higher than the price on amazon.com

Grade Chemical – Grade Chemical is one reliable sodium dehydroacetate manufacturer in China. you can directly purchase from them as much competitive price than the local store price.

Frequently Asked Question

Is sodium Dehydroacetate natural?

The answer is no,  Sodium Dehydroacetate is a chemical compound that has been approved as a food additive by the FDA. It is used to prevent fermentation of apple cider vinegar and other products, which can cause them to spoil.

Is sodium Dehydroacetate safe in food?

The FDA has approved sodium dehydroacetate as a food additive for use in meat products, fruit juices, pickles and sauerkraut. The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) has determined that sodium dehydroacetate is safe for human consumption at levels up to 200 mg/kg body weight per day (BWD).

Is sodium Dehydroacetate bad for you?

Sodium dehydroacetate is a preservative that prevents the growth of harmful microorganisms in food, beverages and cosmetics. It’s used to preserve products that might otherwise be at risk of spoilage due to bacterial contamination.

Sodium Dehydroacetate is not directly toxic to humans, but it can cause allergic reactions in some individuals. It is often used in combination with other preservatives, such as benzoates or sorbates, and these may cause allergic reactions as well.

Is sodium Dehydroacetate toxic?

Sodium Dehydroacetate is not toxic to humans. It is a common ingredient in food products and has been widely used for many years.

Is sodium Dehydroacetate halal?

Sodium Dehydroacetate is not Halal. It is made from a chemical reaction between Sodium Hydroxide and Acetic Acid, both of which are not Halal.


To conclude, Sodium Dehydroacetate is not completely free of side effects. It can be effective in foods as a preservative, especially when utilized at low levels. However, you should avoid it as much as possible because of its potential to create adverse reactions in sensitive people.

We hope you found this article on Sodium Dehydroacetate helpful and that it has cleared up some of the questions you may have had about this potentially dangerous ingredient.

If you have any questions about these additives? Let us know in the below comments.

Sophie Feng

Sophie Feng

Sophie Feng is the author of gradechemical.com, she is the co-founder of the grade chemical network. She has been in grade chemical company since 2017, with a working knowledge of food chemical .

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