What is Crystalline Fructose in Food: Uses, Safe, Benefits, Side effects

What is Crystalline Fructose in Food: Uses, Safe, Benefits, Side effects


Table of Contents

Crystalline fructose also called Pure Fructose, has been a very popular sweetener recently. It is often used in place of table sugar or high fructose corn syrup. Crystalline Fructose is a sugar with a complex chemical structure. It might look like just your ordinary sugar, but there are some important differences between the two. In this article, I will try to tell you everything there is to know about Crystalline Fructose.

What is crystalline fructose?


Crystalline fructose is a sweetener that is made from corn. It’s similar in taste and texture to table sugar (sucrose), but it has a lower glycemic index and it’s about 30 percent sweeter than table sugar.

Crystalline fructose is made from corn syrup, which is then purified to remove the glucose and maltose content. The remaining fructose is then crystallized into crystals, which can be used as a sweetener for products such as yogurt or frozen desserts.

The crystalline fructose you buy at the store may come in either large granules or small crystals, depending on how much moisture it contains. Crystalline fructose is more expensive than high-fructose corn syrup (HFCS), but it contains less moisture, so there isn’t as much of a difference in price when they are compared by weight.



Among naturally occurring sugars, it has the highest sweetness. In comparison to sucrose, it is between 1.3 and 1.8 times sweeter.

Compared with sucrose, its use can be reduced to achieve the same sweetness.

In comparison with other advantages, Its main characteristic is sweetness. As the temperature changes, its sweetness changes as well. Sweetness increases with lower temperature.

Flavor Enhancement


As compared with glucose and sucrose, fructose is perceived first in the tongue, and then quickly disappears.

As fructose’s peak of flavor release occurs before glucose’s and sucrose’s, fructose doesn’t mask glucose’s and sucrose’s flavor release. Therefore, adding crystalline fructose will not improve or maintain the flavor of the beverage.

How is crystalline fructose made?


In addition to sucrose (sugar cane), corn starch can also be used to produce crystalline fructose. After crystallizing with extremely high purity, fructose is milled into desired mesh sizes.

Here is a brief description of the manufacturing process:

1. From Sucrose


Sugar cane can be used as a raw material. Glucose and fructose are converted into sucrose by condensation after a water molecule is removed.

In this way, sucrose can be hydrolyzed into glucose and fructose by absorbing water.

Glucose and fructose are isomers, so glucose can be converted to fructose by glucose isomerase.

2. From Corn starch


Corn starch is broken down into individual glucose molecules to obtain corn syrup, then glucose is converted into fructose using enzymes.

High fructose corn syrup, which typically contains 42% or 55% fructose, is also produced in the same way.

Crystalline fructose VS table sugar?


Crystalline Fructose is a sweetener that has the same sweetening power as table sugar, but it has a lower glycemic index (GI) value.

Crystalline fructose is made from corn starch through an enzymatic process. It contains no additives or GMO ingredients and is considered a natural sweetener. Crystalline fructose also contains zero calories per teaspoon, compared to four calories per teaspoon for regular table sugar (sucrose).

In comparison, sucrose is made up of glucose and fructose bonded together in the naturally occurring form that we know as table sugar. Sucrose has been processed into its pure form – crystals – which means it tastes sweeter than ice cream or milk chocolate while still having the same number of calories.

Is crystalline fructose the same as high fructose corn syrup?


There are two types of fructose used commercially, crystalline fructose and high fructose corn syrup (HFCS), which is a mixture of fructose and glucose.  The main differences between them are as follows:

1. Fructose assay


A portion of the glucose (corn syrup) is converted to fructose by enzymes in order to make HFCS from corn starch. Therefore, it contains glucose as well as fructose.

There are two main types of HFCS:

  • HFCS 42 contains 42% fructose and the rest glucose. The main use of this ingredient is in processed foods and breakfast cereals.
  • This HFCS is primarily used in soft drinks and contains 55% fructose and 25% glucose.

Additionally, HFCS 90 can be crystallized to produce crystalline fructose because it contains 90 percent fructose.

The crystalline fructose, on the other hand, is pure fructose in crystal form. The fructose content is 100%.

2. Convenience


In terms of transportation and uses, it is a better option than HFCS due to its solid form and smaller volume.

3. Glycemic index

Carbohydrates affect blood glucose concentrations according to the Glycemic Index. Fructose has a glycemic index of 19, table sugar has a glycemic index of 65, and glucose has a glycemic index of 100. HFCS has a similar glycemic index to table sugar.

Crystalline fructose metabolizes glucose differently from high fructose corn syrup. In our bodies, glucose is transported and released by insulin. As a result of insulin dysfunction, diabetics’ blood glucose levels will rise (like normal people), but HFCS consumption will harm this population.

As opposed to glucose, fructose does not enter the bloodstream and does not impact blood glucose, since it is converted to fat in the liver. It allows diabetics to control blood glucose levels by using crystalline fructose.

What are the good benefits of crystalline fructose?


Crystalline fructose is a common sweetener that has several benefits. It can be used in place of sugar and other sweeteners like high fructose corn syrup (HFCS). Unlike HFCS, it doesn’t contain any added nutrients such as vitamins or minerals. It also comes with several health benefits.

Here are some of the benefits to using crystalline fructose:

1. No calories

Unlike sugar, crystalline fructose has no calories. This makes it a great substitute for those who want to lose weight and avoid gaining more pounds on their body. People who have diabetes can use this product without worrying about increasing their blood sugar levels or harming their kidneys with excessive sugar intake.

2. Low GI index

The glycemic index (GI) measures how quickly foods raise blood glucose levels after eating them compared to pure glucose or white bread; GI values range from 1 to 100+ depending on the food consumed and how quickly it digests in our bodies. In general, foods with low GI values digest slowly so they don’t cause spikes in blood sugar levels which make you feel hungry again soon after eating them.

3. Calories:

While most people know that fructose is sweeter than sucrose, they may not realize that it also has fewer calories. In fact, crystalline fructose has 40 percent less calories than sucrose. This means that you can use less crystalline fructose in your food products and still get the same sweetness. This can help reduce the calorie content of your products and allow you to offer healthier products to consumers.

4. Solubility:

Crystalline fructose is also more soluble than sucrose and other sugars, which means it dissolves faster in liquids like water or juice. This can improve both their texture and appearance when used in beverages or food products such as salad dressing or sauces. It will also dissolve better in hot liquids like coffee or tea than other sugars, which means that it can be used as an alternative sweetener for hot drinks without having to worry about it leaving clumps behind or causing any problems with the taste of your product


Other namesLevulose, Arabino-hexulose, D-, D-fructose, Fruit Sugar
AppearanceOdorless, white crystalline powder. It is stable to light and heat, and it is easy to absorb moisture. crystalline forms are easy to use and free-flowing.
CAS number57-48-2
Chemical formulaC6H12O6
Molecular weight180.16
SolubilityEasily soluble in water (solubility is 3.5g/mL at 20°C) and ethanol, insoluble in ether.

What is the application of crystalline fructose?



Foods and beverages have long been sweetened with pure crystalline fructose. Additionally, it can be used in cosmetics as a humectant.



According to FDA information, crystalline fructose is used as a flavor enhancer, flavoring agent or adjuvant, formulation aid, nutritive sweetener, processing aid, solvent or vehicle, stabilizer or thickener, and texturizer.



In baking and cake processing, crystalline fructose, which has a good hygroscopicity, can be used.

As a result, it prolongs the shelf life of bakery products by retaining water.

Also, it can accelerate Maillard reactions, which occur when amino acids react with reducing sugars in a bakery. In addition to producing a pleasing brown color, it also produces an appealing aroma when baked.



Compared to table sugar, crystalline fructose has a low glycaemic index and improves and/or maintains flavor. It can be applied to different drinks, including dry mix beverages, flavored or enhanced vitamin waters, carbonated drinks, sports drinks, and energy drinks.

Diabetic Food


Because of its low glycemic response, it is suitable for diabetics.



In foods, crystalline fructose can replace sorbitol and glycerol because of its sweetness, flavor enhancement, and water retention properties. Aside from cereal bars and frozen food, it can also be used in low-calorie products, chocolate milk, yogurt, ice cream, and confections.



According to the cosmetic substances and ingredients database of the European Commission, this ingredient is used as a humectant agent in cosmetics and personal care products.

What are the side effects of crystalline fructose?


The side effects of crystalline fructose are similar to those of other sweeteners, such as high fructose corn syrup and sucrose. Some people may be sensitive to this product, and it can cause bloating and diarrhea in some individuals.

Side Effects


The main side effect of crystalline fructose is its ability to cause intestinal distress. This is due to the fact that the body has difficulty breaking down the sugar molecules found in crystalline fructose. When these molecules reach the small intestine undigested, they draw water from the digestive tract and swell up into hard balls that cannot be broken down further. As a result, you may experience bloating and diarrhea after eating foods containing this sweetener.

Other Potential Side Effects


Crystalline fructose does not contain any calories or carbohydrates, so it does not cause an insulin response in the body or blood sugar spikes like table sugar does. However, since it does contain sugar molecules that are difficult for your body to break down, you may experience an energy crash after eating foods containing this sweetener if you don’t eat enough fat or protein to slow down digestion.

Is crystalline fructose good for you?


Crystalline fructose is a sweetener made from corn. It’s about 70 percent as sweet as sugar, so less is needed to achieve the same level of sweetness. Crystalline fructose is often used in beverages, baked goods and cereals.

Fructose is another type of sugar found naturally in fruits and vegetables. It’s also added to foods to make them sweeter. Fructose is processed differently than other sugars and is commonly used in manufacturing food additives like high-fructose corn syrup (HFCS). Some research suggests that HFCS may cause health problems when consumed in large amounts or over time.

Because of its chemical structure, crystalline fructose doesn’t raise blood glucose levels as much as sucrose or glucose does. This means it may be better for people with diabetes than other types of sugars. However, there isn’t enough evidence to recommend it for diabetes management over other sweeteners at this time.

In addition to being lower on the GI scale than other types of sugars, crystalline fructose has been found to have some antioxidant properties that may help protect against oxidative stress associated with aging.

Is crystalline fructose bad for you?


Crystalline fructose has been found to be safe for human consumption and is used in many common foods, such as juice and yogurt. You can find it in the ingredient list of a product by looking for the term “fructose”.

One study published in 2012 found that rats who consumed a high-fructose diet had higher rates of obesity and high blood sugar levels than rats who consumed a standard diet. This could indicate that crystalline fructose could be harmful to humans, but there have been no other studies to confirm this finding.

Crystalline fructose is also known as high-fructose corn syrup (HFCS), which has been linked with health problems including obesity and diabetes. However, studies have shown that HFCS isn’t any worse than regular sugar and may even be healthier because it contains more antioxidants than sucrose (table sugar).

Where to buy crystalline fructose?


Crystalline fructose can be purchased in bulk at most food supply stores or ordered online through Amazon.com or other online retailers.

Amazon is a great place to find many different products, including crystalline fructose. Amazon has a wide range of prices, quality and shipping options. You can even get free shipping with Amazon Prime.

iHerb has one of the largest selections of products in the world, and they offer free shipping on orders over $50 in the United States. Their prices are also very competitive, so you’ll be able to find good deals here for any supplement or health product that you need.

If you want to buy a large quantity in bulk, you can consider purchasing it from Grade Chemical, which is one reliable crystalline fructose manufacturer in China.

How to find crystalline fructose manufacturers?



You can find crystalline fructose manufacturers by asking for help from your friends and family. You can also do some research on the internet to find a good manufacturer.

You can also find crystalline fructose manufacturers by searching on the internet and making a list of the companies that are offering the services you want. The best way to do this is to search for companies that are providing similar products or services, and then call them up to ask if they have any experience with manufacturing crystalline fructose.

If you don’t know anybody who has used this type of product before, you may have to try calling several different companies until you find one that will be able to meet your needs. It’s important to take notes so that you can remember all the details about each company’s services and prices so that you don’t waste time trying to contact people who won’t be able to help you out.

Frequently asked questions


Is crystalline fructose natural?


Yes, crystalline fructose is natural. It is an extracted product from fruits and vegetables, and it contains all of the nutrients that are found in natural sources.

Is crystalline fructose an artificial sweetener?


Crystalline fructose is not an artificial sweetener. It is a natural sugar found in fruits, honey, and some vegetables. It is a highly concentrated form of fructose, which means it has more calories than regular table sugar. Crystalline fructose can be used as a substitute for sucrose (table sugar) in many recipes.

Is crystalline fructose safe?


Yes, crystalline fructose is safe. Crystalline fructose is made from corn and is used as a sweetener in many processed foods and beverages. It has been approved by the Food and Drug Administration (FDA) as an ingredient in food products.

Is crystalline fructose Safe for Pregnant?


Crystalline fructose is safe for pregnant women to consume. Crystalline fructose is also known as “high fructose corn syrup” (HFCS), which is a mixture of glucose and fructose that has been processed from corn starch.

Is crystalline fructose Vegan?


Crystalline fructose is a type of sugar that, unlike table sugar or sucrose, does not contain any glucose. This means that crystalline fructose is vegan, as it is not processed with animal products.

Is crystalline fructose Halal?


The answer is yes, crystalline fructose is Halal. You can find crystalline fructose in many products like sugar and maple syrup. Crystalline fructose is not made from alcohol or any other ingredients that are Haram.

Is crystalline fructose Kosher?


Yes. Crystalline fructose is Kosher, as it’s made from corn starch, which is kosher.

Is crystalline fructose Gluten free?


Yes, crystalline fructose is gluten-free. Crystalline fructose is a sweetener made from cane sugar, corn starch (which can be genetically modified), or fruit. It has been approved by the Food and Drug Administration for use in foods labeled “gluten-free,” and it does not contain any wheat proteins or other ingredients derived from wheat.



Crystalline Fructose is widely used as an alternative sweetener in various processed foods. It is sourced from sugarcane. The main benefit of this polyol sucrose-based sweetener is its health and diet benefits. Much lesser likely to cause any dental caries when consumed along with the other food compared to other sugar substitutes. However, some side effects such as gas, bloating, diarrhea and cramping have been reported when consumed in large amounts. It often contains traces of mercury, cadmium, and lead which are major health concerns for everyone.

if you have any feedback on the crystalline fructose? Let us know in the below comments.

Sophie Feng

Sophie Feng

Sophie Feng is the author of gradechemical.com, she is the co-founder of the grade chemical network. She has been in grade chemical company since 2017, with a working knowledge of food chemical .

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